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KMID : 0380620140460060665
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Korean Journal of Food Science and Technology
2014 Volume.46 No. 6 p.665 ~ p.670
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The Antiproliferative Effects of Compounds Isolated from Schisandra chinensis
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Suh Won-Se
Park So-Yeon
Min Byung-Sun
Kim Sea-Hyun
Song Jeong-Ho
Shim Sang-Hee
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Abstract
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We isolated twelve lignans and three terpenoids were isolated from the n-hexane fraction of Schisandra chinensis extract. Using spectroscopic data and comparison with available literature, the following compounds were identified: (1) wuweizisu C, (2) gomisin N, (3) deoxyschisandrin, (4) gomisin A, (5) schisandrin, (6) chamigrenal, (7) schisanlactone D, (8) methylgomisin O, (9) angeloylgomisin O, (10) (?)-gomisin L2, (11) schisandronic acid, (12) (?)-gomisin L1, (13) (+)- gomisin K3, (14) gomisin J, and (15) tigloylgomisin H. Notably, this was the first finding that compound (8) was isolated from this plant. Each compound was evaluated for its in vitro cytotoxic activities toward HL-60 (human leukemia), HeLa (human cervical carcinoma), and MCF-7 (breast cancer) cell lines. Compounds (7), (8), and (9) exhibited strong cytotoxic effects on HL-60 (IC50 7.37, 6.60, and 8.00 μM, respectively), whereas compound (6) exhibited weak cytotoxicity towards MCF-7 (IC50 30.50 μM). In addition, compound (8) showed the strongest activity towards HeLa cells (IC50 1.46 μM).
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KEYWORD
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Schisandra chinensis, cytotoxicity, lignan, methylgomisin O
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